If you have an HTTP Client unit test, you can try the option of making a Wrapper interface in your solution like this here: 
http://stackoverflow.com/questions/10693955/stubbing-or-mocking-asp-net-web-api-httpclient.  As for two parameters in the unit test, you can do the following.. 
Guid id = Guid.NewGuid();
string baseUri = ConfigurationManager.AppSettings["BaseUrl"] + @"/"
 + ConfigurationManager.AppSettings["ApiVersion"] + @"/";
Dto responseDto = new Dto();
httpClient.Setup(x => x.PostAsync(new Uri(baseUri + "AdditionalUrlHere/Stuff"), It.IsAny()))
                .Callback((uri, dto) => responseDto = dto)
                .ReturnsAsync(id);